Transmembrane Topography and Evolutionary Conservation of Synaptophysin

Transmembrane topography and evolutionary conservation of synaptophysin.

Synaptophysin is the major integral membrane protein of small synaptic vesicles. Its primary structure deduced from rat and human complementary DNA sequences predicts that synaptophysin contains four transmembrane regions and a carboxyl-terminal domain having a novel repetitive structure. To elucidate the transmembrane organization of this protein in the synaptic vesicle, five antipeptide antib...

Evolutionary Conservation Biology: Introduction

Evolutionary conservation and functional roles of ncRNA

Non-coding RNAs (ncRNAs) are a class of transcribed RNA molecules without protein-coding potential. They were regarded as transcriptional noise, or the byproduct of genetic information flow from DNA to protein for a long time. However, in recent years, a number of studies have shown that ncRNAs are pervasively transcribed, and most of them show evidence of evolutionary conservation, although le...

Bayesian Inference of Subglacial Topography Using Mass Conservation

We develop a Bayesian model for estimating ice thickness given sparse observations coupled with estimates of surface mass balance, surface elevation change, and surface velocity. These fields are related through mass conservation. We use the Metropolis-Hastings algorithm to sample from the posterior probability distribution of ice thickness for three cases: a synthetic mountain glacier, Storgla...

Genetic conservation: our evolutionary responsibility.

The conservation of the crop varieties of traditional agriculture in the centers of genetic diversity is essential to provide genetic resources for plant improvement. These resources are acutely threatened by rapid agricultural development which is essential for the welfare of millions. Methodologies for genetic conservation have been worked out which are both effective and economical. Urgent a...